姓名：张文鹤
性别：女
籍贯：辽宁沈阳
联系电话：17521679697
E-Mail：zhangwenhe306@163.com
个人主页：
职称/职务：副教授
通讯地址：辽宁省本溪高新技术开发区华佗大街26号
邮政编码：110072
学习/工作经历：2012.09-2016.06 外围买球app十大排行 药物制剂专业 学士
2016.09-2021.12 外围买球app十大排行 微生物与生化药学专业 博士
（2019.04-2021.12于中国科学院上海有机化学研究所联合培养）
2022.03至今 外围买球app十大排行 微生物与细胞生物学教研室 专任教师
研究方向：多种类型生物催化剂的开发、蛋白质工程改造与应用；药物中间体（主要涉及手性中间体）绿色合成路线的设计；天然产物生物合成途径相关功能酶的研究。
兼职情况：
科研/获奖情况：用于卤代芳杂环砌块合成的黄素依赖型卤化酶的挖掘与重塑,国家自然科学基金青年科学基金项目（82204219），项目负责人
教学/指导研究生情况：承担本科生《微生物学与免疫学》、《微生物学实验》、《免疫学实验》、《细胞生物学实验》课程。
发表论文/出版著作：
近五年发表参与SCI文章8篇，其中一区文章3篇，以第一作者发表文章3篇,以通讯作者参与发表文章2篇，按时间顺序排列如下：
1. Hengyu Li,Wenhe Zhang,Changli Che,Huibin Wang,Yutian Jia,Xiao Gao,Xian Jia,Qin Bin,Song You.Rationally Engineering the Cofactor Specificity of LfSDR1 for Biocatalytic Synthesis of the Key Intermediate of Telotristat Ethyl. ChemCatChem,2022,(影响因子：5.497)
2.Jiaxiang Lv,Yaqi Ding, Chenming Huang , Lingling Guo , Jiali Fang , Xian Jia ,Wenhe Zhang, Song You,Bin Qin.Enzymes and Chemo-Enzymes Catalyzed Stereodivergent Synthesis.PharmaceuticalFronts,2022, 04(03):121-135.
3.Jiyang Guo,Xiao Gao,Dong Qian,Huibin Wang,Xian Jia,Wenhe Zhang, Bin Qin,Song You.Efficient synthesis of an apremilast precursor andchiral β-hydroxy sulfones via ketoreductasecatalyzedasymmetric reduction.Organic & Biomolecular Chemistry, 2022, 20(10): 2081-2085.(影响因子：3.89)
4.Wenhe Zhang, Fei Wang, Yilin Wang,Song You,HaixuePan,GongliTang.Identification and Characterization of Enzymes Catalyzing Early Steps inMiharamycin and Amipurimycin Biosynthesis.Organic Letters,2021, 23(22), 8761–8765.(影响因子：6.072)
5. Hengyu Li,Wenhe Zhang,Xianyan Jiang,Huibin Wang,Qi Wang,Jiajun Wang,Xian Jia,Bin Qin,Song You. Development of an Enzymatic Process for the Synthesis of the Key Intermediate of Telotristat Ethyl. Advanced Synthesis & Catalysis, 2021,363(2): 540-548.(影响因子：5.981)
6. Fei Wang,Wenhe Zhang, Juan Zhao, Wenjia Kang, Shengyang Wang, Biao Yu, Hai-Xue Pan,Gongli Tang. Characterization of Miharamycin Biosynthesis Reveals a Hybrid NRPS–PKS to Synthesize High-Carbon Sugar from a Complex Nucleoside. Journal of the American Chemical Society, 2020,142(13): 5996-6000.(影响因子：16.383)
7.Wenhe Zhang, Tianhui Zhu, Hengyu Li, Fengyu Qin,Feiting Zhang, Rui Zhang,Xian Jia,Bin Qin,Song You. Key sites insight on the stereoselectivity of four mined aldo-keto reductases toward α-keto esters and halogen-substituted acetophenones[J]. Applied Microbiology and Biotechnology, 2019,103(1),6119–6128.(影响因子：5.56)
8. Fengyu Qin,Bin Qin, Wenhe Zhang, Yalin Liu, Xin Su, Tianhui Zhu, Jingping Ouyang, Jiyang Guo, Yuxin Li, Feiting Zhang, Jun Tang, Xian Jia,Song You.Discovery of a switch between Prelog and anti-Prelog reduction toward halogen-substituted acetophenones in short-chain dehydrogenase/reductases[J]. ACS Catalysis, 2018,8(7): 6012-6020.(影响因子：13.7)
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